Zymo Research DNase I is a recombinant endonuclease that cleaves single- and double-stranded DNA. It digests DNA more efficiently than other DNase I, making it optimal for sensitive applications like NGS (RNA-seq) and PCR. It is extensively purified, and quality controlled to ensure RNase-free and protease-free.

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Fastest DNA digestion for sensitive applications
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No detectable RNases or proteases
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Withstand multiple freeze-thaw cycles
and vortexing

General Applications

  • Removal of DNA from protein and RNA samples.
  • Removal of DNA template after in vitro transcription.
  • DNA labeling by nick-translation.
  • Preparation of RNA samples prior to downstream applications (NGS, RT-PCR, etc.).

Highest DNA Digestion Activity

Zymo Research DNase I is 10x faster at digesting DNA than other DNases.

Complete DNA Digestion

DNA was completely digested after incubation with DNase I. Salmon sperm DNA (1.5 µg) was incubated with 0.1 U DNase I for 10 minutes at 25 °C.

Retains Activity After Vortexing

DNase I activity maintained after three rounds of one minute vortexing at high speed.
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